OUR THERAPYClinical and Scientific Publications

Melanoma-specific survival of patients with uveal melanoma and liver metastases diagnosed between 2005 and 2021

Therapeutic Advances in Medical Oncology. 2024;16. doi:10.1177/17588359241273020
Wiens L, Grözinger G, Dittmann H, et al.

Read More

Hepatic chemosaturation with melphalan in patients with primary or secondary liver tumors with or without extrahepatic tumor manifestation

ESMO Gastrointestinal Oncology, Volume 5, 2024, 100082, ISSN 2949-819
R. Veelken, S. Ebel, A. Schindler, F. Lordick, M.F. Struck, C. Girbardt, F. Ziemssen, D. Seehofer, T. Denecke, T. Berg, F. van Bömmel

Read More

Hepatic and Overall Progression-Free Survival After Percutaneous Hepatic Perfusion (PHP) as First-Line or Second-Line Therapy for Metastatic Uveal Melanoma

Ann Surg Oncol. 2024 August 22. https://doi.org/10.1245/s10434-024-16039-5
Ghali, H., Dugan, M.M., Aflatooni, S. et al.

Read More

Efficacy and Safety of the Melphalan/Hepatic Delivery System in Patients with Unresectable Metastatic Uveal Melanoma: Results from an Open-Label, Single-Arm, Multicenter Phase 3 Study

Ann Surg Oncol. 2024 May 4. doi: 10.1245/s10434-024-15293-x. Epub ahead of print. PMID: 38704501.

Zager JS, Orloff M, Ferrucci PF, Choi J, et al.

Read More

Predictive Parameters in Patients Undergoing Percutaneous Hepatic Perfusion with Melphalan for Unresectable Liver Metastases from Uveal Melanoma: A Retrospective Pooled Analysis

Cardiovasc Intervent Radiol. 2022 Sep;45(9):1304-1313. doi: 10.1007/s00270-022-03225-9. Epub 2022 Aug 3. PMID: 35922562; PMCID: PMC9458688.

Tong TML, Samim M, Kapiteijn E, Meijer TS,et al.

Read More

New Perspectives in Unresectable Cholangiocarcinoma? Evaluation of Chemosaturation with Percutaneous Hepatic Perfusion as a Palliative Treatment option

Clin Exp Metastasis 40, 95–104 (2023). https://doi.org/10.1007/s10585-022-10193-4

Dewald, C.L.A., Becker, L.S., Meine, T.C. et al.

Read More

Safety and Efficacy of Combined Melphalan Percutaneous Hepatic Perfusion (M-PHP) and Ipilimumab Plus Nivolumab (IPI+NIVO) in Metastasized Uveal Melanoma (mUM): First Results of the Phase Ib Part of the CHOPIN Trial.

JCO 40, 9560-9560(2022). DOI:10.1200/JCO.2022.40.16_suppl.9560

Tong TML, Burgmans MC, Speetjens FM, et al.

Read More

Combining Melphalan Percutaneous Hepatic Perfusion with Ipilimumab Plus Nivolumab in Advanced Uveal Melanoma: First Safety and Efficacy Data from the Phase Ib Part of the Chopin Trial

Cardiovasc Intervent Radiol 46, 350–359 (2023). https://doi.org/10.1007/s00270-022-03338-1

Tong, T.M.L., Burgmans, M.C., Speetjens, F.M. et al.

Read More

FOCUS Phase 3 Trial Results: Percutaneous Hepatic Perfusion (PHP) with Melphalan for Patients with Ocular Melanoma Liver Metastases (PHP-OCM-301/301A).

J Clin Oncol. 2022;40:16(suppl):9510. doi: 10.1200/JCO.2022.40.16_suppl.9510

Jonathan S. Zager et al.

Read More

Chemosaturation with Percutaneous Hepatic Perfusion of Melphalan for Metastatic Uveal Melanoma

Melanoma Res. 2022;32(2):103–111. doi: 10.1097/CMR.0000000000000806

Modi S, Gibson T, Vigneswaran G, et al.

Read More

Repeated Percutaneous Hepatic Perfusion with Melphalan Can Maintain Long-term Response in Patients with Liver Cancers

Cardiovasc Intervent Radiol 45, 218–222 (2022). https://doi.org/10.1007/s00270-021-02983-2

Veelken, R., Maiwald, B., Strocka, S. et al.

Read More

Liver Metastasis Restrains Immunotherapy Efficacy via Macrophage-mediated T Cell Elimination

Nat Med 27, 152–164 (2021). https://doi.org/10.1038/s41591-020-1131-x

Yu, J., Green, M.D., Li, S. et al.

Read More

A New Option for the Treatment of Intrahepatic Cholangiocarcinoma: Percutaneous Hepatic Perfusion with CHEMOSAT Delivery System

Cells. 2021;10(1):70. doi: 10.3390/cells10010070

Ferrucci PF, Cocorocchio E, Bonomo G, Varano GM, Della Vigna P, Orsi F.

Read More

Regulatory T Cell Control of Systemic Immunity and Immunotherapy Response in Liver Metastasis

Sci Immunol. 2020;5:eaba0759. doi:10.1126/sciimmunol.aba0759

Lee JC, Mehdizadeh S, Smith J, et al.

Read More

Unresectable Hepatic Metastasis of Uveal Melanoma: Hepatic Chemosaturation with High-Dose Melphalan—Long-Term Overall Survival Negatively Correlates with Tumor Burden

Radiol Res Pract. 2020;2020:5672048. doi: 10.1155/2020/5672048

Brüning R, Tiede M, Schneider M, et al.

Read More

Percutaneous Hepatic Perfusion with Melphalan in Patients with Unresectable Ocular Melanoma Metastases Confined to the Liver: A Prospective Phase II Study

Ann Surg Oncol 28, 1130–1141 (2021). https://doi.org/10.1245/s10434-020-08741-x

Meijer, T.S., Burgmans, M.C., de Leede, E.M. et al.

Read More

Chemosaturation with Percutaneous Hepatic Perfusion is effective in Patients with Ocular Melanoma and Cholangiocarcinoma

J Cancer Res Clin Oncol 146, 3003–3012 (2020). https://doi.org/10.1007/s00432-020-03289-5

Schönfeld, L., Hinrichs, J.B., Marquardt, S. et al.

Read More

Immunotherapy and the Interventional Oncologist: Challenges and Opportunities—A Society of Interventional Oncology White Paper

Radiology. 2019;292(1):25–34. doi: 10.1148/radiol.2019182326

Erinjeri JP, Fine GC, Adema GJ, et al.

Read More

Chemosaturation with Percutaneous Hepatic Perfusion of Melphalan for Liver-dominant Metastatic Uveal Melanoma: a Single Center Experience

Cancer Imaging. 2019;19:31. doi: 10.1186/s40644-019-0218-4

Artzner C, Mossakowski O, Hefferman G, et al.

Read More

Safety of Percutaneous Hepatic Perfusion with Melphalan in Patients with Unresectable Liver Metastases from Ocular Melanoma Using the Delcath Systems’ Second-Generation Hemofiltration System: A Prospective Non-randomized Phase II Trial

Cardiovasc Intervent Radiol 42, 841–852 (2019). https://doi.org/10.1007/s00270-019-02177-x

Meijer, T.S., Burgmans, M.C., Fiocco, M. et al.

Read More

Percutaneous Hepatic Perfusion (Chemosaturation) with Melphalan in Patients with Intrahepatic Cholangiocarcinoma: European Multicentre Study on Safety, Short-term Effects and Survival

Eur Radiol 29, 1882–1892 (2019). https://doi.org/10.1007/s00330-018-5729-z

Marquardt S, Kirstein MM, Brüning R, et al.

Read More

Percutaneous Hepatic Perfusion with Melphalan in Uveal Melanoma: A Safe and Effective Treatment Modality in an Orphan Disease

Eur Radiol. 2019;29:1882–1892. doi: 10.1007/s00330-018-5729-z

Karydis I, Gangi A, Wheater MJ, et al.

Read More

Chemosaturation Percutaneous Hepatic Perfusion: A Systematic Review

Adv Ther. 2016;33:2122–2138. doi: 10.1007/s12325-016-0424-4

Vogel A, Gupta S, Zeile M, et al.

Read More